The Two Modes of Visual Processing: Implications for Spatial Orientation

The roles of the focal and ambient visual systems in spatial orientation are discussed. The two modes are defined and compared. The contribution of each system is illustrated through examples such as spatial disorientation/motion sickness, vehicle guidance/night driving, visual narrowing under stress/cortical brain damage, and aircraft instrumentation. Emphasis is placed on the need for testing procedures for the ambient system

Learning together: Lessons from a collaborative curriculum design project

Based on an action research project implemented at two South African universities, we argue that content and language integration (ICL) collaborative partnerships benefit not only from collaboration between language and content specialists, but in addition, from collaboration between language specialists, general education specialists and content specialists from a variety of disciplines. However, as we illustrate below, these benefits may be accompanied by substantial challenges. We make a further claim, for the value of a transformative approach towards collaboration for content and language integration, in which the teacher/researchers engage in their practice in a critical and reflexive manner, and by so doing, foster their own deep learning, as well as the deep learning of the students

The barriers, benefits and training needs of clinicians delivering psychological therapy via video

BACKGROUND: Due to the COVID-19 pandemic, mental health services have had to offer psychological therapy via video with little time to prepare or mitigate potential problems. Identifying the barriers, benefits and training needs highlighted by clinicians may support the effective delivery of care. METHOD: Changes in the mode therapy sessions were delivered in during 2020 were assessed in two high-volume psychological therapies services. Sixty-six therapists completed a survey about their experiences of delivering therapy via video. RESULTS: The lockdown in March 2020 precipitated a dramatic shift from face-to-face to telephone and video-delivered sessions. Most clinicians (89%) found video-based sessions acceptable. Barriers to effective delivery included technological issues, problems with online platforms, and feeling more tired after sessions. Benefits included generalised learning from behavioural work, improvements in efficiency and in the therapeutic relationship, particularly in comparison with telephone-based sessions. Tutorials and support guides were recommended to maximise use of sessions via video. CONCLUSIONS: Video-delivered therapy was liked by clinicians and preferred to telephone-based sessions. Issues with platforms, internet connections and access for patients need addressing, local troubleshooting guides, video-based tutorials and greater support for low-intensity therapists to maximise uptake of video sessions where appropriate, may be beneficial

Dietary nitrate-induced increases in human muscle power: High versus low responders

Maximal neuromuscular power is an important determinant of athletic performance and also quality of life, independence, and perhaps even mortality in patient populations. We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. The present investigation was designed to identify factors contributing to this interindividual variability. Healthy men (n = 13) and women (n = 7) 22-79 year of age and weighing 52.1-114.9 kg were studied using a randomized, double-blind, placebo-controlled, crossover design. Subjects were tested 2 h after ingesting beetroot juice (BRJ) either containing or devoid of 12.3 ± 0.8 mmol of NO3- . Plasma NO3- and nitrite (NO2- ) were measured as indicators of NO bioavailability and maximal knee extensor speed (Vmax ), power (Pmax ), and fatigability were determined via isokinetic dynamometry. On average, dietary NO3- increased (P < 0.05) Pmax by 4.4 ± 8.1%. Individual changes, however, ranged from -9.6 to +26.8%. This interindividual variability was not significantly correlated with age, body mass (inverse of NO3- dose per kg), body mass index (surrogate for body composition) or placebo trial Vmax or fatigue index (in vivo indicators of muscle fiber type distribution). In contrast, the relative increase in Pmax was significantly correlated (r = 0.60; P < 0.01) with the relative increase in plasma NO2- concentration. In multivariable analysis female sex also tended (P = 0.08) to be associated with a greater increase in Pmax. We conclude that the magnitude of the dietary NO3- -induced increase in muscle power is dependent upon the magnitude of the resulting increase in plasma NO2- and possibly female sex

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food

3,4-and 3,5-disubstituted 2-pyridones using an intermolecular cycloaddition/cycloreversion strategy: toward the synthesis of aristopyridinone A

The intermolecular cycloaddition of pyrazinone precursors with alkyne substrates was evaluated. The resulting regioisomeric [2.2.2]-diketopiperazine alkene cycloadducts were diverted into 2-pyridone products through cycloreversion of the [2.2.2]-bicyclic intermediates. New insights into the regioselectivity of pyrazinone azadiene Diels-Alder reactions as well as cycloreversion reactivity were revealed in this study. Synthetic sequences using this [4+2]/r[4+2] strategy were determined that can produce predominantly the 3,5-disubstituted 2-pyridone alkaloid structures; pyridones featuring the 3,4-substitution pattern are observed as the minor regioisomeric products. (C) 2015 Elsevier Ltd. All rights reserved

Deep infrared observations of the puzzling central X-ray source in RCW103

1E 161348-5055 (1E 1613) is a point-like, soft X-ray source originally identified as a radio-quiet, isolated neutron star, shining at the center of the 2000 yr old supernova remnant RCW103. 1E 1613 features a puzzling 6.67 hour periodicity as well as a dramatic variability over a time scale of few years. Such a temporal behavior, coupled to the young age and to the lack of an obvious optical counterpart, makes 1E 1613 a unique source among all compact objects associated to SNRs. It could either be the first low-mass X-ray binary system discovered inside a SNR, or a peculiar isolated magnetar with an extremely slow spin period. Analysis of archival IR observations, performed in 2001 with the VLT/ISAAC instrument, and in 2002 with the NICMOS camera onboard HST unveils a very crowded field. A few sources are positionally consistent with the refined X-ray error region that we derived from the analysis of 13 Chandra observations. To shed light on the nature of 1E 1613, we have performed deep IR observations of the field with the NACO instrument at the ESO/VLT, searching for variability. We find no compelling reasons to associate any of the candidates to 1E 1613. On one side, within the frame of the binary system model for the X-ray source, it is very unlikely that one of the candidates be a low-mass companion star to 1E 1613. On the other side, if the X-ray source is an isolated magnetar surrounded by a fallback disc, we cannot exclude that the IR counterpart be hidden among the candidates. If none of the potential counterparts is linked to the X-ray source, 1E 1613 would remain undetected in the IR down to Ks>22.1. Such an upper limit is consistent only with an extremely low-mass star (an M6-M8 dwarf) at the position of 1E 1613, and makes rather problematic the interpretation of 1E 1613 as an accreting binary system.Comment: 26 pages, 5 figures. Accepted for publication in Ap

Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic

Background: General population surveys have shown that some groups, particularly young women, experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for current and future lockdowns. / Methods: Mean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services (Improving Access to Psychological Therapies) in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). The proportion of scores which were above the clinical thresholds for ‘caseness’ each week were compared, and scores between groups based on gender, age group, and ethnicity, were also compared. / Results: Confirmed community transmission in the UK (26/02/2020-03/03/2020) and the announcement of the national ‘lockdown’ (23/03/2020) were associated with significant increases in anxiety symptom scores. ‘Lockdown’ was associated with a decrease in depression scores. These changes were not maintained during lockdown. Significant increases in depression and anxiety were observed at week 23, as restrictions were eased. / Limitations: This was an exploratory analysis in two services only. Residual confounding and selection biases cannot be ruled out. / Conclusions: Differences in the weekly average symptom scores were short-term; they did not continue throughout ‘lockdown’ as might have been expected, except among older people. Replication of this study in other settings and investigating the potential benefits of more regular reviews or more intensive treatments for at-risk groups, are warranted

Geodesic Deviation in Kaluza-Klein Theories

We study in detail the equations of the geodesic deviation in multidimensional theories of Kaluza-Klein type. We show that their 4-dimensional space-time projections are identical with the equations obtained by direct variation of the usual geodesic equation in the presence of the Lorentz force, provided that the fifth component of the deviation vector satisfies an extra constraint derived here.Comment: 5 pages, Revtex, 1 figure. To appear in Phys. Rev. D (Brief Report

U Sco 2010 outburst: a new understanding of the binary accretion disk and the secondary star

We present optical and NIR spectroscopic observations of U Sco 2010 outburst. From the analysis of lines profiles we identify a broad and a narrow component and show that the latter originates from the reforming accretion disk. We show that the accretion resumes shortly after the outburst, on day +8, roughly when the super-soft (SSS) X-ray phase starts. Consequently U Sco SSS phase is fueled (in part or fully) by accretion and should not be used to estimate $m_{\mathrm{rem}}$, the mass of accreted material which has not been ejected during the outburst. In addition, most of the He emission lines, and the HeII lies in particular, form in the accretion flow/disk within the binary and are optically thick, thus preventing an accurate abundance determination. A late spectrum taken in quiescence and during eclipse shows CaII H&K, the G-band and MgI b absorption from the secondary star. However, no other significant secondary star features have been observed at longer wavelengths and in the NIR band.Comment: Accepted for publication on A&A. 12 pages and 12 figures (a few are multiple figures